Why Choose LGC, Biosearch Technologies

Larger scale oligonucleotide synthesis has been growing rapidly in demand for therapeutic and pre-clinical applications. The surge in the need for the development of oligos as aptamers, antisense, and RNAi therapeutics, and the requirement for highly modified oligos falls into perfect harmony with Biosearch Technologies’ manufacturing expertise.

Experienced resources

We have a highly trained and dedicated process development team comprising MS and PhD scientists who offer support from synthesis to method development and validation working in a cross-functional environment to better understand and serve customers’ needs. Our ‘Quality by Design’ approach offers the ability to optimize production from milligram to hundreds of grams according to your custom project requirements. We are committed to delivering solutions for difficult problems in a timely fashion without compromising quality, price, reliability, and reproducibility.

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square feet of modern lab and office space



oligos per day



oligos per day


nmol ⇨ mmol

scales for synthesis & purification

Chemistries and production

Various production lines to support the product development lifecycle

Key Chemistries

  • DNA, RNA, 2’ OMe, 2’ Fluoro
  • Fully phosphorothioated oligos and modified backbones
  • Wide range of nucleic acid analogues including aptamers, gapmers, chimeras, and PEG-ylation
  • Over 250 oligo modifications including cholesterol, biotin, and fluorogenic dyes.

Analytical services

  • Appearance
  • Molecular Weight
  • Molecular Sequence
  • Identity by HPLC
  • Thermal Melt (Tm)
  • Assay
  • Water content (%w/w)
  • pH
  • Sodium content
  • Purity and Impurity Profile (HPLC, UPLC, LCMS)
  • Residual solvents
  • Heavy metals (or full metal scan)
  • Analytical method development (ICH Q8)
  • Analytical method validation (ICH Q2)
  • Customized development
  • Quality by design
  • Bioburden
  • Bacterial endotoxins

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