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2’-O-Methyl-U-Suc-CPG is used for synthesis of oligonucleotides that contain nuclease resistant 2’-O-methyl linkages to prevent degradation. The 2’-O-Methyl-U-Suc-CPG requires no special handling or deprotection reagents. The 500 Å CPG is best suited for the synthesis of RNA sequences up to 50-mers in length.

Properties:

  • Appearance:

    White Powder

Product usage:

  • Synthesis conditions:

    Follow the instrument manufacturer's protocol when using this product.

  • Cleavage conditions:

    Use concentrated ammonia for 90 minutes at 25°C or for 30 minutes at 60°C.

  • Deprotection conditions:

    When using fast deprotecting amidites (eg. C-Ac, G-DMF) use concentrated ammonia. When using standard amidites (eg. C-Bz, G-iBu) use concentrated ammonia for 5 hours at 60 °C. This RNA support is compatible with deprotection chemistries used with 2’ Fluoro; 2' modified phosphoramidites and TBDMS protected reagents.

  • AMA is not recommended for sequences containing uridine bases.
    Image of cleaved and deprotected structure:
    100405c.gif

  • The mass this product adds after conjugation and work-up (the additional mass seen by mass spectrometry) is:

    320.19

Storage and handling:

  • Shipping conditions:

    Ambient

  • Storage conditions:

    -15 to -30 °C

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