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Oligo modification Oligo purification

Whether you require labeled, unlabeled oligos, or PCR primers, LGC Biosearch Technologies can meet your exact needs as we offer custom modifications at extremely competitive rates. Most oligos are shipped in less than five to seven working days. Certificates of Analysis are available upon request.

The "Build Your Custom Oligos" Quick Order form allows you to build your custom DNA, RNA, and even DNA/RNA hybrid sequences. If you would like to order a dual-labeled probe, please use our Dual-Labeled BHQ™ Probes quick order form. We also offer other fluorogenic probe and primer formats.

Don’t see the modification you are looking for, or require a larger synthesis scale? We would be happy advise if we can create your specific oligo. Just ask us at

A few ordering tips...


Building oligos with RNA bases

  • Indicate that your are inserting an RNA base by selecting rA, rC, rG or rU from the Internal Modification drop down menu or by checking the RNA checkbox if your sequence is entirely RNA.

Building oligos with internal modification(s)

  • If your oligo requires an internal modification, make a selection and then click the ADD button. The internal modification will be inserted at the point of the cursor.

  • Adding an internal modification annotated by T(...) indicates that a Thymidine base is attached to the internal modification. Please be aware that an additional T base will be introduced into the sequence when adding such an internal modification.

Building oligos with wobble/degenerate bases (What are wobbles?)

  • To ensure the most efficient processing of your oligo, use IUPAC code when entering wobble/degenerate bases in the Sequence Entry field instead of using parentheses, e.g. (A/G), (A/G/C/T), etc.

Synthesis scale vs. final yield

  • The synthesis scale and final yield are not the same due to the several steps involved in probe/primer synthesis. These steps include coupling of each base, cleavage of oligonucleotide from solid support and purification steps. The combination of these steps cause the final yield of the oligo to be less than the synthesis scale (starting material).

Ordering oligos delivered in plates

  • Ordering a LOT of oligos? Visit our Oligos in plates webpage where you can download our column or row format excel order forms. Prices start at $0.15 per base with a minimum order of 48 oligos.

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Custom Oligo #{{$index + 1}}

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Catalog #
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This sequence is too short. Click here for help.
Final yield may be reduced for oligos longer than 50 bases.
This oligo contains more than 150 bases. Click here for help.
This oligo contains multiple 'wobbles' bases. If this oligo is intended to function as a PCR primer we advise limiting to no more that 6 oligo species. Please ensure that you intent to incorperate this degeneracy in the oligo and are aware of the impact on oligo function. Contact technical support for more advice (
This oligo contains more than 80 RNA bases. Please reduce this sequence length or click here for help.
If you are ordering an LNA please use an excel order form and email to
Modifications incompatible. If you would like to order an oligo with an Amino and an internal or 3' Methylene Blue the 5' modification must be Amino C6.
Are you trying to build a fluorogenic probe? If so, please use the appropriate order form. Otherwise, this oligonucleotide will need to be quoted for pricing.
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