RNase R for circular RNA synthesis (circRNA)
Circular RNA (circRNA) presents an opportunity to enhance pharmaceutical stability and biostability. The covalently closed structures of circRNA are resistant to RNA exonucleases and eliminate the need for expensive capping technology.
Ensure translation accuracy in circular RNA synthesis by in vitro transcription (IVT) with RNase R (Epicentre RNase R). RNase R is a magnesium-dependent 3′ → 5′ exoribonuclease that digests linear RNAs after circularisation, enhancing protein production.
LGC Biosearch Technologies™ manufactures RNase R (Epicentre RNase R) in our ISO-13485 accredited manufacturing facilities in Middleton, WI USA with convenient international fulfillment through our global operations.
Custom projects for circular RNA synthesis
Backed by 25 years of expertise in enzyme development and production, we also offer custom formulations of in vitro transcription enzymes (IVT enzymes). Like all of our enzymes, we manufacture custom enzymes in our ISO-13485 accredited facilities. We offer customisations to support you from early method development to large-scale production.
Popular enzyme customisations for circular RNA synthesis:
- Different concentrations
- Triton free or glycerol free
- Custom QC based on your requirements
- Batch reservation
- Lot retention
- Custom storage or reaction buffers
- Bulk dispense
In addition to customising our enzymes to meet your requirements, you can also partner with us to manufacture your proprietary IVT enzyme constructs in our ISO-13485 accredited facilities.
Circular RNA vaccines against SARS-CoV-2 and emerging variants
Marek’s Disease Virus Virulence Genes Encode Circular RNAs
Circular RNAs Represent a Novel Class of Human Cytomegalovirus Transcripts
What goes around comes around: Artificial circular RNAs bypass cellular antiviral responses
A flexible, efficient, and scalable platform to produce circular RNAs as new therapeutics
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