Biosearch Technologies Issued Two New Patents

NOVATO, CA (Wednesday, March 3, 2010) — Biosearch Technologies, Inc. (Biosearch), announced today that it has been awarded U.S. Patent Nos. 7635598 and 7635762. These patents demonstrate Biosearch’s continued commitment to the advancement in the field of pro-fluorescent assays.

“Luminescent Metal Ion Complexes” (US7635762), developed by Ronald Cook, Matthew Lyttle, and Mary Katherine Johansson, describes how a non-traditional fluorophore composed of a metal ion chelate can be efficiently attached to a biomolecule. This technology was used to develop Biosearch’s Pulsar® 650 reporter label, notable for its large Stokes’ Shift (absorption maximum at 450 nm; emission maximum at 650nm).

“Inducible fluorescence assay” (US7635762), developed by Ronald Cook, Eliana Saxon Armstrong, and Hans E. Johansson, describes a novel reporter system based on the use of an azoreductase enzyme to permanently destroy the quenching ability of Biosearch’s BHQ® dyes, thereby activating any linked fluorophore. The versatility of the new assays system in this invention dramatically expands the ability to perform multiplexed, cell-based reporter gene assays used in high throughput screening.

About Biosearch Technologies, Inc.

Biosearch Technologies, Inc. is a privately held, ISO 9001:2008 certified company, located in northern California. Founded in 1993, Biosearch is a leader in the design, development and manufacture of sophisticated oligonucleotide-based tools. Products include fluorophores (CAL Fluor®, Quasar® and Pulsar® dyes) and dark quenchers (Black Hole Quencher® dyes) to be included in custom-synthesized probe formats for real-time, quantitative PCR and other genomic-based applications.

In addition to basic R&D applications, Biosearch now leverages its demonstrated expertise in fully assembled RUO kits and the cGMP manufacture of oligonucleotide components for molecular diagnostic assays. As a Class I ASR manufacturer, Biosearch’s manufacturing processes conform to all applicable GMP requirements per 21 CFR Part 820. Biosearch markets include pharmaceutical, in-vitro diagnostic, biotech, ag/bio, environmental and food testing, public health, and biodefense sectors.

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