Solid support performance can be a significant factor in reducing oligonucleotide synthesis cost and ensuring a quality end-product.
Our controlled pore glass has been refined for maximum oligo purity and yield through advanced production techniques to optimise control of particle size and shape, pore size, pore volume and specific surface area.
In general, large scale oligo synthesis for therapeutic applications requires high loaded 500-600 Å and small to medium scale synthesis for diagnostic or research use require higher pores sizes. Explore our current top-selling CPG products for therapeutic oligos using the links below.
Bulk and column-packed controlled pore glass products by LGC Biosearch Technologies are summarised in this table with quick links to help you find what you’re looking for.
|Type of CPG||Modification available|
|DNA||dA, dC (Ac), dC (Bz), dG (iBu), dG (dmf), dT|
|RNA||rA (Bz), rC (Ac), rC (Bz), rG (iBu), rG (dmf), rU
2'OMe rA (Bz), 2'OMe rC (Ac), 2'OMe rC (Bz), 2'OMe rG (iBu), 2'OMe rG (dmf), 2'OMe rU
|RNA (pac)||rA (pac), rG (iPr-Pac), rG (iPr-Pac)|
|Reverse synthesis||3'DMT dT, 3' DMT dA (Bz), 3' DMT dC (Bz)|
|LNA||LNA A (Bz), LNA C (Bz), LNA G (dmf), LNA T|
|2'F||2'F A (Bz), 2'F C (Ac), 2'F G (iBu), 2'F U|
|BHQ (1000Å/500Å)||BHQ-1, BHQ-2, BHQ-3|
|Other fluorophores and quenchers||CAL Fluor, TAMRA, Fluorescein, Cyanine, Dabcyl, DDQ, BBQ|
|Universal||DMTr off (N-iPr)|
|Cell delivery||GalNAc, Tocopherol, cholesterol|