The published research articles from our R&D scientists show the range of expertise in our company.

HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer. Teschendorff;; A.E.; Lee, S.H.; Jones, A.; Fiegl, H.; Kalwa, M.; Wagner, W.; Chindera, K.; Evans, I.; Dubeau, L.; Orjalo, A.; Horlings, H.M.; Niederreiter, L.; Kaser, A.; Yang, W.; Goode, E.L.; Fridley, B.L.; Jenner, R.G.; Berns, E.M.; Wik, E.; Salvesen, H.B.; Wisman, G.B.; van der Zee, A.G.; Davidson, B.; Trope, C.G.; Lambrechts, S.; Vergote, I.; Calvert, H.: Jacobs, I.J.: Widschwendter, M. Genome Med. 2015  7(1), 108. doi: 10.1186/s13073-015-0233-4.

Female bias in Systemic Lupus Erythematosus is associated with the differential expression of X-linked Toll-Like Receptor 8. McDonald, G.; Cabal, N.; Vannier, A.; Umiker, B.; Yin, R.H.; Orjalo A.V. Jr.: Johansson, H.E.; Han, J.H.; Imanishi-Kari, T. Front Immunol. 2015 6, 457. doi: 10.3389/fimmu.2015.00457.

Application of an RNA amplification method for reliable single-cell transcriptome analysis. Suslov, O.; Silver, D.J.; Siebzehnrubl, F.A.; Orjalo, A.; Ptitsyn, A.; Steindler, D.A. Biotechniques. 2015 59(3), 137-48. doi: 10.2144/000114331.

Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. Yoon, J.H.; Abdelmohsen, K.; Kim, J.; Yang, X.; Martindale, J.L.; Tominaga-Yamanaka, K.; White, E.J.; Orjalo, A.V.; Rinn, J.L.; Kreft, S.G.; Wilson, G.M. Gorospe, M. Nat Commun. 2013 4, 2939. doi: 10.1038/ncomms3939.
Coactivators enable glucocorticoid receptor recruitment to fine-tune estrogen receptor transcriptional responses. Bolt, M.J.; Stossi, F.; Newberg, J.Y.; Orjalo, A.; Johansson, H.E.; Mancini, M.A. Nucleic Acids Research 2013, doi: 10.1093/nar/gkt100.

Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells. Mandal, S.; Mandal, A.; Johansson, H.E.; Orjalo, A.V.; Park, M.H. PNAS 2013, doi: 10.1073/pnas.1219002110. See also:

Post-translational modification by ß-lysylation is required for the activity of E. coli Elongation Factor P (EF-P). Park, J.H.; Johansson, H.E.; Aoki, H.; Huang, B.; Kim, H.Y.; Ganoza, M.C.; Park, M.H. J Biol Chem 2012, 287(4), 2579-90 doi: 10.1074/jbc.M111.309633.

Stellaris™ fluorescence in situ hybridization (FISH) probes: a powerful tool for mRNA detection. Orjalo, Jr., A.; Johansson, H.E.; Ruth, J.L. Nature Methods 2011, 8, pp I-III.

BTI1, an Azoreductase with pH-Dependent Substrate Specificity. Johansson, H.E.; Johansson, M.K.; Wong, A.C.; Armstrong, E.S.; Peterson, E.J.; Grant, R.E.; Roy, M.A.; Reddington, M.V.; Cook, R.M. Appl. Environ. Microbiol. 2011, doi:10.1128/AEM.02289-10.

Convenient synthesis of (E)-5-aminoallyl-2'-deoxycytidine and some related derivatives. Reddington, M.V.; Cunninghan-Bryant, D. Tetrahedron Letters 2011, 52 (2), 181-183.

The BTI1 azoreductase colorimetric and fluorometric reporter system. Johansson, H.E.; Johansson, M.K., Wong;  A., Peterson, E.J.;  Armstrong, E.S.;  Grant, R.E.;  Reddington, M.V.; Cook, R.M.  FASEB J. 2009, 23, 502.17.

Synthesis and Properties of Phosphonic Acid Containing Cyanine and Squaraine Dyes for Use as Fluorescent Labels. Reddington, M.V. Bioconjugate Chem 2007, 18(6), 2178-2190.

Methylotrophic Methanogens in the Water Column of an Upwelling Zone with a Strong Oxygen Gradient off Central Chile. Levipan, H.A.; Quiñones, R.A.; Johansson, H.E.; Urrutia, H. Microbes and Environments 2007, 22(3), 268-278.

Solid Phase Synthesis of Dual Labeled Peptides: Development of Cell Permeable Calpain Specific Substrates. Polster, B.M.; Arze, R.; Lyttle, M.H.; Nicholls, D.G.; Hudson, D. Int. J. Pep. Res. Therapeut. 2007, 13, 83-91.

Development of a Red-Shifted Fluorescence-Based Assay for SARS-Coronavirus 3CL Protease: Identification of a Novel Class of Anti-SARS Agents from the Tropical Marine Sponge Axinella corrugata. Hamill, P.; Hudson, D.; Kao, R.Y.; Chow, P.; Raj, M.; Xu, H.; Richer, M.J.; Jean, F. Biol. Chem., 2006, 387, 1063-1074.

Choosing Reporter-Quencher Pairs for Efficient Quenching Through Formation of Intramolecular Dimers. Johansson, M.K. In Methods in Molecular Biology, v. 335; V.V. Didenko, Ed; Humana Press: Totowa, NJ, 2006; pp 17-29.

Time Gating Improves Sensitivity in Energy Transfer Assays with Terbium Chelate/Dark Quencher Oligonucleotide Probes. Johansson, M.K.; Cook, R.M.; Xu, J.; Raymond, K.N. J. Am. Chem. Soc. 2004, 126(50), 16451-16455.

Intramolecular Dimers: A New Design Strategy for Fluorescence-Quenched Probes. Johansson, M.K.; Cook, R.M. Chem. Eur. J. 2003, 9, 3466-3471. (This paper was also the subject of this issue's cover art)

Photoluminescence and Electrochemiluminescence of a Ru(II)(bpy)3-Quencher Dual-Labeled Oligonucleotide Probe. Wilson, R.; Johansson, M.K. Chem. Commun. 2003, 2710-2711.

Intramolecular Dimers: A New Strategy to Fluorescence Quenching in Dual-Labeled Oligonucleotide Probes. Johansson, M.K.; Fidder, H.; Dick, D.; Cook, R.M. J. Am. Chem. Soc. 2002, 124, 6950-6956.

Evaluation of New Linkers and Synthetic Methods for Internal Modified Oligonucleotides. Walton, T.A. ; Lyttle, M.H.; Dick, D.J.; Cook, R.M. Bioconjugate Chem. 2002, 13, 1155-1158.

New Reagents and Methods for the Synthesis of Internal and 3'-Labeled DNA. Lyttle, M.H.; Walton, T.A.; Dick, D.J.; Carter, T.G.; Beckman, J.H.; Cook, R.M. Bioconjugate Chem. 2002, 13, 1146-1154.

Fmoc Chemistry Compatible Methods for Thio-Ligation Assembly Of Proteins. Biancalana, S.; Hudson, D.; Songster, M.F.; Thompson, S.A. In Peptides: The Wave of the Future; Lebl, M.; Houghten, R.A., Eds.; American Peptide Society: San Diego, 2001; pp 117-118.

New Quencher Derivatives for Fluorescent Quenching Peptide Assays. Walton, T.A.; Dick, D.J.; Hudson, D.; Johansson, M.K.; Lyttle, M.H.; Songster, M.F.; Cook, R.M. In Peptides: The Wave of the Future; Lebl, M.; Houghten, R.A., Eds.; American Peptide Society: San Diego, 2001; pp 54-55.

Improved Synthetic Procedures for 4,7,2',7'-Tetrachloro- and 4',5'-Dichloro-2',7'-dimethoxy-5(and 6)-carboxyfluoresceins. Lyttle, M.H.; Carter, T.G.; Cook, R.M. Org. Process Res. Dev. 2001, 5, 45-49.

A Tetramethyl Rhodamine (Tamra) Phosphoramidite Facilitates Solid-Phase-Supported Synthesis of 5'-Tamra DNA. Lyttle, M.H.; Carter, T.G.; Dick, D.J.; Cook, R.M. J. Org. Chem. 2000, 65, 9033-9038.

Fmoc Chemistry Compatible Thio-ligation Assembly of Proteins. Biancalana, S.; Hudson, D.; Songster, M.F.; Thompson, S.A. Lett. Pept. Sci. 2000, 7, 291-297.

Orthogonal Methods for the Synthesis of Multiply Labeled Peptide Probes and Substrates. Songster, M.F.; Biancalana, S.; Cook, R.M.; Dick, D.J.; Hudson, D. In Peptides for the New Millennium; Fields, G.B.; Tam, J.P.; Barany, G., Eds.; Kluwer: Dordrecht, The Netherlands, 2000; pp 111-112.

A Phosphate Bound Universal Linker for DNA Synthesis. Lyttle, M.H.; Dick, D.J.; Hudson, D.; Cook, R.M. Nucleosides Nucleotides 1999, 18, 1809-1824.

Matrix Assisted Synthetic Transformations: A Mosaic of Diverse Contributions. II. The Pattern Is Completed. Hudson, D. J. Comb. Chem. 1999, 1, 403-457.

Matrix Assisted Synthetic Transformations: A Mosaic of Diverse Contributions. I. The Pattern Emerges. Hudson, D. J. Comb. Chem. 1999, 1, 333-360.

An Investigation of the Role of Environment, Spacer Arm and Site Isolation Effects in PEG-Polystyrene Graft Copolymers. Hudson, D.; Cook, R.M.; Lyttle, M.H.; Adams, J.H.; Songster, M.F.; White, P. In Peptides: 1998; Bajusz, S.; Judecz, F., Eds.; Akadémiai Kiadó: Budapest, Hungary, 1999; pp 40-41.

A Reinvestigation of the Preparation, Properties, and Applications of Aminomethyl and 4-Methylbenzhydrylamine Polystyrene Resins. Adams, J.H.; Cook, R.M.; Hudson, D.; Jammalamadaka, V.; Lyttle, M.H.; Songster, M.F. J. Org. Chem. 1998, 63, 3706-3716.