We offer innovative superparamagnetic bead-based as well as solution-based nucleic acid purification technologies for fast and convenient isolation of high-quality DNA and RNA from a broad range of sample materials and species.
The sbeadex Lightning is an innovation in nucleic acid isolation - as it delivers high-quality DNA in high yield with a simple, ultrafast 3-step/5-minute protocol, saving time and costs. It comes as a modular system allowing to compile a kit optimised for a specific sample type.
Learn moresbeadex™ magnetic microparticles enable the automated high-throughput extraction and purification of high quality DNA and RNA preparations from a wide range of materials including plant, blood, cells and tissues, bacteria, viruses and forensic material.
Learn moreMasterPure purification reagents provide DNA and RNA purification from same workflow. Depending on the amount of nucleic acid required and size of the sample, different MasterPure variants are available.
Learn moreHigh-throughput, cost-effective nucleic acid isolation from a broad range of sample materials such as animal and plant tissues, blood or forensic samples. The highly pure nucleic acids are suitable for many downstream applications including PCR, restriction enzyme analysis and sequencing/NGS.
Learn moreSample material can vary greatly in consistency as well as in sugar, protein and fat composition - all of which can affect the quality and purity of the isolated nucleic acid and the subsequent performance of downstream applications. To provide the most efficient and effective purification method, LGC Biosearch Technologies offers not only a range of different extraction chemistries/technologies but also the capacity to develop tailor-made kit systems optimised to a particular sample type/matrix and/or application.
| sbeadex Lightning™ | sbeadex™ | mag™ | MasterPure™ | |
|---|---|---|---|---|
| Decision aid | If you want top DNA quality with the simplest, fastest mag-bead based workflow on the market | If you are looking for high quality DNA with high yield across many sample types with a robust, automation ready mag bead solution | If you look for a flexible and cost-effective mag bead method that works with a classical polarity based binding mechanisms based on chaotropic buffers | If you look for a gentle, precipitation-based chemistry that yields high-molecular weight DNA |
| Technology | Surface-modified superparamagnetic silica coated particles | Surface-modified superparamagnetic particles | Superparamagnetic silica coated particles | Solution-based precipitation chemistry |
| Mechanism of action | Novel simultaneous binding and washing step(1) | Novel two-step binding mechanism(1) | Classic polarity-based binding mechanism | Cell debris, proteins and DNA are precipitated and separated using highly concentrated salt solutions and isopropanol |
| Flexibility | Flexible format (single, 96-well, 384-well), scalable protocols, adaption of lysis to sample material, off-the shelf and modular kit format available | Flexible format (single, 96-well, 384-well), scalable protocols, adaption of lysis to sample material | Flexible format (single, 96-well, 384-well), scalable protocols, adaption of lysis to sample material | Flexible format (single, 96-well), scalable protocols, adaption of volume |
| Matrices | Plant material, livestock samples, tissue and cells | Plant material, tissue, cells, blood, saliva, swab, plasma, serum, urine etc. bacterial | Plant material, animal tissue, whole blood, buffy coat, buccal swabs, saliva, bacteria, yeast, fungi, microorganisms | Plant material, cultured cells, tissue/paraffin-embedded tissue, blood, serum, plasma, saliva, sputum, urine, yeast, bacteria |
| Grade of automation | Automated high-throughput extraction on common liquid handling systems + MagRod (magnetic rod) instruments with increased throughput vs. traditional methods | Automated high-throughput extraction on common liquid handling systems + MagRod instruments | Automated high-throughput extraction on common liquid handling systems + MagRod instruments | Semi-automated extraction (centrifugation required) on common liquid handling systems |
| Benefits |
|
|
|
|
1Our surface-coated superparamagnetic particles do not require the use of vacuum filtration or centrifugation steps; hence, they are well-suited to automation.
For research use only. Not for use in diagnostic procedures.
| Europe, Middle East, and Africa | |
|---|---|
| UK | +44 1992 470 757 |
| Germany | +49 30 1663 54600 |
| North America, Latin America | |
| Wisconsin, USA | +1 888 575 9695 |
| Asia Pacific | |
| China | +8621-22509000 |
| Singapore | +65 6734 4800 |
