Does LGC Biosearch Technologies synthesize minor groove binder (MGB) probes?
Minor groove binder (MGB) probes are proprietary to Life Technologies (part of Thermo Fisher) and unavailable through LGC Biosearch Technologies. Instead, we offer an alternative chemistry called BHQplus®, but BHQplus probes do not represent a direct replacement for MGB probes. Nevertheless, BHQplus represents a duplex stabilizing chemistry to allow for shorter sequences with elevated melting temperatures than their sequences would indicate. BHQplus probes are specially designed for SNP genotyping, and to detect more difficult targets such as AT-rich targets or short conserved regions.
For more information, please visit our BHQplus Probes webpage.