The MOE-G modification adds a 2'-O-(2-Methoxyethyl)guanosine internally or to the 5’ end of an oligonucleotide. 2'-MOE nucleotides confer increased nuclease resistance and are commonly used in applications for posttranscriptional silencing of specific target genes; including steric blocking antisense oligos (ASO), aptamers, gapmer ASOs, and small interfering RNA (siRNA). In addition, 2'-MOE nucleotides exhibit high binding affinity towards complimentary RNA as well as reduced cytotoxicity.
Properties:
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Formula:
C13H17N5O9P
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Molecular Weight:
418.28
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Absorption Maximum (Lambda Max):
0
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Extinction Coefficient at Lambda max:
11500
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Extinction Coefficient at 260 nm:
11500
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Fluorescence Maximum:
0
Product usage:
-
The mass this product adds after conjugation and work-up (the additional mass seen by mass spectrometry) is:
403.29
