Cohort studies

Researchers use LGC technologies for a wide variety of studies. Our customers’ data speaks volumes about the work we do. Use our publication search.

Researchers use our technologies for a wide variety of studies, including many considered to be some of the largest and most prestigious in the world:

  • The GEFOS (GEnetic Factors for Osteoporosis) GENOMOS consortium
  • The Whitehall II study

Study publications

The GEFOS (GEnetic Factors for Osteoporosis) GENOMOS consortium

  • A global consortium of prominent research institutes studying genetic factors involved in Osteoporosis.
  • 24 countries around the world including USA, Denmark, France, Germany, Greece, Italy, The Netherlands, Norway, Spain, Sweden and the UK.
  • With them we have genotyped over 85,000 DNA samples and 83 SNPs.
  • Examples of recent published research:
    •  "Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture." Nature genetics 44.5 (2012): 491-501, in which  Estrada et al. highlight loci associated with bone-mineral density and risk of fracture from genome-wide association studies
    •  "Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium." Human molecular genetics (2014): ddt675, in which Moayyeri et al. reveal the effect of several genes and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology

The Whitehall II study

  • The Whitehall II study was established in 1985 by Professor Sir Michael Marmot and his UCL team to investigate the importance of social class for health by following a cohort of 10,308 working men and women.
  • The study is famous for its contributions to understanding the relationship between social status and genetic factors in the UK.
  • We have provided nucleic acid purification and SNP genotyping for 10,000 samples with several projects including DNA storage, sample tracking and sample handling.