Skip to content Skip to navigation menu
New Site Launched: Looking for oligos? Visit our new oligo and Stellaris dedicated platform at oligos.biosearchtech.com
Happy Holidays! View our holiday closures and shipping schedule. HOLIDAY SCHEDULE
 
cancel
  1. Home
  2. Nucleic Acid Chemistry Reagents and Instruments
  3. Modified Oligo Synthesis Reagents
  4. Structural Studies
  5. Duplex Modifiers
  6. Propyne dC (DBF) Amidite

Propyne dC (DBF) Amidite

Propyne dC (DBF) Amidite

Propyne dC (DBF) Amidite

Phosphoramidite used to incorporate a C-5 propyne modified dC either internally or at the 5' end of an oligonucleotide.

Key features

Show Hide
  • Enhances base pairing.
  • Confers duplex stability and melting temperatures are raised by 2.8° per substitution.
  • Confers nuclease resistance and binding affinity of antisense oligos.
Item ID NACN1-017
TBD
Add to basket to request a quote

Product information

Substitution of C-5 propynyl-dC (pdC) for dC and C-5 propynyl-dU (pdU) for dT are effective strategies to enhance base pairing. Duplex stability and melting temperatures are raised by 2.8° or 1.7° per substitution of pdC or pdU respectively. Such Tm modification is used in Turbo Taqman probes for example. C5-propyne pyrimidine modifications are sometimes added to increase nuclease resistance and binding affinity of antisense oligos.

Product usage:

    Image of cleaved and deprotected structure:

Access support

Need some support with placing an order, setting up an account, or finding the right protocol?

Contact us