5-(2-Furyl)-dU CE-Phosphoramidite is a phosphoramidite of a small, fluorescent nucleoside that is an isosteric mimic of thymidine.⁽¹⁾ This probe has been shown to pair with adenine to form a stable duplex. DNA probes constructed to contain this moiety at a selected sequence position show a significant emission enhancement when hybridization results in an opposing abasic residue as compared to an opposing adenine residue.^1a This property makes BA0346 useful for the preparation of probes that are designed to detect sequence-specific depurination and depyrimidination.

Ref:

1. (a) Greco, N.J.; Tor, Y. J. Am. Chem. Soc. 2005, 127, 10784-10785. (b) Greco, N.J.; Tor, Y. Nature Protocols, 2007, 2, 305-316.