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  2. Nucleic Acid Chemistry Reagents and Instruments
  3. Modified Oligo Synthesis Reagents
  4. Modified Nucleoside Phosphoramidites
  5. 7-Deaza-dA CE-Phosphoramidite

7-Deaza-dA CE-Phosphoramidite

7-Deaza-dA CE-Phosphoramidite, BULK (g), Glass Screw-Top

7-Deaza-dA CE-Phosphoramidite

7-Deaza-dA CE-Phosphoramidite, BULK (g), Glass Screw-Top

CAS No.:107134-59-8

Useful phosphoramidite for modification of base pairing and metal chelating characterisitcs of purine nucleosides through elimination of the N7 nitrogen.
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Item ID BA0001-C000
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Product information

The N7 imidazole nitrogen of purine nucleosides is known to take part in non-Watson-Crick hydrogen bonding and in metal chelation. "Deleting" the N7 nitrogen by replacing it with a CH group is a useful modification that has been accomplished in DNA oligonucleotides using the phosphoramidite of 2'-deoxytubercidin, namely 7-Deaza-dA CE-Phosphoramidite,(1), which was useful in showing that N7 of dA is an important hydrogen bond acceptor site for the endodeoxyribonuclease EcoRI.

Ref:

  1. (a) Seela, F.; Kehne, A. Biochemistry, 1987 26, 2232-2238. (b) Seela, F.; Berg, H.; Rosemeyer, H. Biochemistry, 1989, 28, 6193-6198.

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